“The IoD Directors’ Economic Confidence Index, which measures business leader optimism in prospects for the UK economy, fell to -65 in November 2024 from -52 in October and for the fourth month running.“
“People whose surnames start with U, V, W, X, Y or Z tend to get grades 0.6% lower than people with A-to-E surnames. Modern learning management systems sort papers alphabetically before they’re marked, so those at the bottom are always seen last, by tired, grumpy markers. A few teachers flip the default setting and mark Z to A, and their results are reversed.“
Ozempic seems to be changing the second hand clothes market, creating a surge in plus-size women’s apparel sales. Size 3XL listings have doubled over the last two years
“Evo is a genomic foundation model that enables prediction and generation tasks from the molecular to genome scale. Using an architecture based on advances in deep signal processing, Evo is trained on 7 billion parameters with a context length of 131 kilobases at single-nucleotide resolution. Evo captures two fundamental aspects of biology—the multimodality of the central dogma and the multiscale nature of evolution.“
Elliott are after Honeywell with a $5bn stake and a letter arguing for a break-up.
This chart from their letter shows how splitting up has led to improved performance – which so far the stock market has rewarded handsomely (e.g. CARR is worth more now than UTX was pre-spins).
The transformation of technology to the -as-a-service model has led to many positives, yet it has led to a situation where users don’t own anything.
This creates vulnerabilities – “years ago websites were made of files; now they are made of dependencies.”
“If the current trend of technology is sweeping us in a direction of “everything is amazing, but nothing is ours”, Technology that’s Actually Yours could be the next great counter-trend.“
