What if drug development could one day be like engineering?
Artificial intelligence has the potential to make this a reality, as is so well explored in this accessible Forbes profile.
One of the most exciting parts they highlight is de novo protein design i.e. building proteins from nothing (this is a nice post about it from Derek Lowe).
Three excellent questions about the future of semiconductors and AI.
“First, is AI additive to the semis market? Will purchases of AI chips increase overall demand for semis, or will they merely replace purchases of other chips?
How will the market for AI Inference semis play out? How big will it be and who will win share?
Can Nvidia be displaced from the market dominance it currently enjoys?“
“There seems to be an unwritten rule on Wall Street: If you don’t understand it, then put your life savings into it.” Lynch.
“If you’re not willing to react with equanimity to a market price decline of 50% two or three times a century, you’re not fit to be a common shareholder and you deserve the mediocre result you’re going to get.” Munger.
“When you want to test the depths of the stream, don’t use both feet.” Chinese proverb.
Fascinating chart showing how scientific revolutions progressed 1300-1850 between different countries.
“Here, we leverage large datasets of individual biographies (N = 22,943) and present the first estimates of scientific production during the late medieval and early modern period (1300–1850). Our data reveal striking differences across countries, with England and the United Provinces being much more creative than other countries, suggesting that economic development has been key in generating the Scientific Revolution.“
Despite the sharp rise in Fed Funds rate, company net interest payments have actually fallen.
“We have concluded that a sizeable proportion of huge, fixed-rate borrowings during 2020/21 still survives on company balance sheets in variable rate deposits. Companies have effectively played the yield curve in reverse and become net beneficiaries of higher rates, adding 5% to profits over the last year instead of deducting 10%+ from profits as usual.”
There has been a “seismic shift” in global financial markets – “the use of collateral, notably in the form of government securities” becoming “ubiquitous” at the cost of directly assessing borrower cash flow.
Pushed along by policy this switch from relationship to transactions banking has resulted in an unprecedented broadening and deepening of financial markets, especially derivatives.
Yet, this has also created huge vulnerabilities in financial markets, according to a new BIS article.
