Biogen Saga

  • Earlier this year we covered Biogen’s decision to file Aducanumab (their experimental treatment for Alzheimer’s Disease) here and here.
  • This saga reignited this past week with the publication of FDA adcom documents which on the surface looked positive sending the shares soaring only to be voted down (8-1) at the meeting on Friday sending them crashing down.
  • This really good blog post discusses these events and why it is always important to read all the details.
  • The final FDA outcome is yet to be determined (Adcom decisions aren’t binding) and as previously highlighted could be political.

Online is Taking Over Pt II

  • Eye opening stat from Domino’s Pizza courtesy of The Transcript.
  • “There was a trend toward digital ordering pre-pandemic, and that significantly accelerated during the pandemic. I don’t expect customers to go back to calling on the phone, I expect digital ordering to continue to grow post-pandemic. And I feel that we are very well-positioned in that space today with 75% of our sales in the U.S. digital as we sit here today

Online Taking Over

  • 40% of new (straight) relationships in the USA started online.
  • Due to Covid this is likely higher today than in 2017 where the data ends.
  • “The intensity with which singles are swiping and chatting is visible across all Match Group dating apps, which include Tinder, OKCupid, Match.com, Hinge and Plenty of Fish. Amarnath Thombre, the chief executive of Match Group Americas, said that messages were up 30 to 40 percent on most of the company’s apps compared with the same time last year.
  • Source.

Sugar

  • Interesting long read on the quest to chemically redesign sugar.
  • In 1880 the average American would have lived and died never having encountered a single manufactured candy. Today the average American ingests more than nineteen teaspoons added sugar every day.
  • Despite a turn in public opinion against sugar, alternatives don’t work – “none of sugar’s artificial replacements offer anything close to the same range of functionality. Sucrose reduces ice-crystal formation in ice cream; it adds crispness to baked goods, volume to dough, and a mouth-filling viscosity to drinks; it improves emulsion stability in dressings, reduces grittiness in chocolate, and even increases shelf life.

Daniel Ek Interview

  • Interview with Spotify founder and CEO Daniel Ek.
  • Interesting insights throughout.
  • A great meeting has three key elements: the desired outcome of the meeting is clear ahead of time; the various options are clear, ideally ahead of time; and the roles of the participants are clear at the time.
  • I think that’s the single largest source of optimization for a company: the makeup of their meetings. To be clear, it’s not about fewer meetings because meetings serve a purpose. Rather, it’s key to improve the meetings, themselves. A lot of my efforts focus on teaching people this framework. Ironically, I find that most people are just challenged by that stuff.
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