Remdesivir Update

  • Remdesivir, an antiviral, is one of the leading drugs in development for COVID-19.
  • Recent published cohort analysis was supportive.
  • In this cohort of patients hospitalized for severe Covid-19 who were treated with compassionate-use remdesivir, clinical improvement was observed in 36 of 53 patients (68%).
  • Crucial to understand the limitations of this data – the need for a randomised placebo controlled trial.
  • Gilead’s (GILD) CEO Daniel O’Day in an open letter expresses this.
  • These trials are ongoing with results coming in end of April/May.
  • While it may feel like a long wait for data given the urgency of the situation, it has been only two months since the first clinical trials began. Given that it can take a year or more to have the first clinical data for an investigational treatment, it is remarkable that we expect to have the first remdesivir trial data so soon.” 
  • The latest buzz from Chicago is also just a snapshot and drawing conclusions is “scientifically unsound“.
  • We will have to wait – but not long.
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